Trodelvy Injection price in India

 Trodelvy: Injection for intravenous infusion

The FDA approved medicine Trodelvy contains Sacituzumab govitecan-hziy that is used to treat patients with metastatic triple-negative breast cancer (mTNBC) who have received at least two prior therapies for metastatic disease. This indication is approved under accelerated approval based on tumor response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials. This medicine is supplied in 180 mg lyophilized powder in single-dose vials to administer intravenously. The active ingredient in the vials is Sacituzumab govitecan-hziy with inactive ingredients  2-(N-morpholino) ethane sulfonic acid (MES), polysorbate 80 and trehalose dihydrate. One should not substitute Trodelvy for or use with other drugs containing irinotecan or its active metabolite SN-38.  

One can readily purchase Trodelvy 180 mg injection readily from certified generic medicine suppliers in India. Indian Pharma Network is one of the WHO-GDP certified pharmaceutical suppliers, supplying quality medicines for more than 8 years

Trodelvy: Dosage and Schedule

The medicine Trodelvy contains Sacituzumab govitecan-hziy is used to treat patients with metastatic triple-negative breast cancer (mTNBC) who have received at least two prior therapies for metastatic disease. Trodelvy comes in the form of single-use vials in 180 mg to administer intravenously. The recommended dose of Trodelvy is 10 mg/kg administered as an intravenous infusion once weekly on Days 1 and 8 of 21-day treatment cycles. One should continue treatment until disease progression or unacceptable toxicity and should not administer Trodelvy injection at doses greater than 10 mg/kg.   

One should administer Trodelvy as an intravenous infusion only and should not administer as an intravenous push or bolus. In the first infusion one should administer infusion over 3 hours. Observe patients during the infusion and for at least 30 minutes following the initial dose, for signs or symptoms of infusion-related reactions. In case of subsequent infusions one should administer infusion over 1 to 2 hours if prior infusions were tolerated and observe patients during the infusion and for at least 30 minutes after infusion. 

Healthcare professionals recommend prior to each dose of Sacituzumab govitecan 180 mg, premedication for prevention of infusion reactions and prevention of chemotherapy-induced nausea and vomiting (CINV).  

Trodelvy : Suppliers in India 

The medicine Trodelvy is a Trop-2-directed antibody and topoisomerase inhibitor conjugate indicated for the treatment of  Unresectable locally advanced or metastatic triple-negative breast cancer (mTNBC) and Locally advanced or metastatic urothelial cancer (mUC). This medicine comes in single-dose vials in 180 mg for intravenous infusion. 

There are several certified suppliers of Trodelvy in India, and one can buy this medicine at a reasonable price. If you want to know more, call us at 18008891064.

Enhertu: Know about Medication

 Enhertu is a HER2-directed antibody and topoisomerase inhibitor conjugate used for the treatment of: 

adult patients with unresectable or metastatic HER2-positive breast cancer who have previously received two or more anti-HER2-based regimens in the metastatic setting. 

adult patients with locally advanced or metastatic HER2-positive gastric or gastroesophageal junction adenocarcinoma who have previously received a trastuzumab-based regimen.

Recommended Dosage: The recommended dosage of  Enhertu 100 mg Injection for Metastatic Breast Cancer and Locally Advanced or Metastatic Gastric Cancer is 5.4 mg/kg and 6.4 mg/kg respectively, administered as an intravenous infusion once every three weeks (21-day cycle) until the disease is progressive or unacceptable toxicity occurs. 

In case a planned dose is missed or delayed, administer as promptly as possible; avoid waiting until the next planned cycle. Adjust the schedule of administration in order to maintain a 3 week interval between doses. The infusion is administered at the dose and rate the patient tolerated in the most recent infusion.

Serious, life-threatening, or fatal interstitial lung disease (ILD), including pneumonitis, may occur in patients treated with trastuzumab deruxtecan injection. Monitor patients for signs/symptoms of ILD. Promptly assess evidence of ILD. Evaluate patients with suspected interstitial lung disease by radiographic imaging. 

Serious neutropenia, including febrile neutropenia, may occur in patients treated with Trastuzumab Deruxtecan. Monitor complete blood counts before initiating treatment and before each dose. On behalf of the severity of neutropenia, this medicine may require dose interruption or reduction. 

Patients treated with enhertu injection may be at higher risk of having left ventricular dysfunction. LVEF needs to be assessed before initiating treatment and at regular intervals throughout the treatment. LVEF decrease needs to be managed through therapy interruption. 

Depending on its mechanism of action, enhertu can cause fetal harm if used by a pregnant woman. Pregnancy status needs to be verified prior to the initiation of treatment with this drug. Women should not breastfeed while on treatment and for 7 months after the final dose of Enhertu. 

Documentation & Availability:

What documents are required to import ENHERTU to India?

ENHERTU (fam-trastuzumab deruxtecan-nxki) can be imported by patients or GOVT hospitals on the name of the patients only. 

The following documentation required to import the product:

• Valid prescription from a qualified doctor.
• Patients diagnostic reports
• Patients id proof (issued by government of India)

How does order be confirmed?

The order will be confirmed only after the receipt of:

• Valid prescription of Doctor
• Import permit if applicable

Is ENHERTU available in India?

ENHERTU (trastuzumab deruxtecan injection) is a (prescription drug, prescription medication or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed.

IPN (Indian Pharma Network) helps import cancer medicines on the named patient supply (NPS). Indian Pharma Network is facilitator providing input

On availability of enhertu in India (Ahmedabad, Mumbai, Kolkata, Hyderabad, Chennai, Delhi, Bangalore and Pune etc.)

• Medicine Price.
• Finding Genuine and reliable source from Canada, Europe, USA and Australia
• Ensuring 100% transparency.

ENHERTU can be made available to patients, doctors and hospitals at Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Srinagar, Jammu, Jaipur, Chandigarh, Ludhiana, Noida, Gurgaon, Lucknow and Pune and other cities in India. The order will be confirmed only after the receipt of a valid prescription from the doctor and import permit.

IPN (Indian Pharma Network) can facilitate the supply of ENHERTU (prescription medicines) to all locations in the world and in India after fulfilling the legal requirement (if applicable)

Please contact +91-9310090915 | Toll-Free No: 1800-889-1064 or write us at info@indianpharmanetwork.in for price of enhertu 100 mg injection price in India. 

We take guarantee of quality and delivery anywhere in the world as per the buyer’s requirements.

Sourcing & Delivery:

Indian Pharma Network is able to source the ENHERTU (Cancer Treatment Medicines) from across the globe, and has the ability to supply. Indian Pharma offers its customers worldwide access to the best available treatment.

Indian Pharma Network is able to dispense any valid prescription in the shortest possible time. All prescriptions are dispensed and checked by registered pharmacists and dispatched to the Patient's address only from New Delhi, India.

FAQs:

What is the Generic Name for the trade name drug Enhertu®?

Fam-trastuzumab Deruxtecan-nxki is Generic Name for the trade name drug Enhertu®.

Is Enhertu® approved by the FDA?

Yes, Enhertu® is approved by the FDA. Date of approval: May 4, 2022.

What is the dosage and form of Enhertu® supplied?

Enhertu® is supplied for injection: 100 mg lyophilized powder in a single-dose vial for intravenous administration. 

Does Enhertu® cause hair loss?

Yes, hair loss is the most common adverse reaction of Enhertu®. 

Is Enhertu® chemotherapy or immunotherapy?

Enhertu® is a chemotherapy and it is also a targeted therapy anti-cancer medicine. 

What are the most common side effects due to Enhertu®? 

Most common side effects due to Enhertu® in patients with breast cancer were nausea, WBC count decreased, fatigue, vomiting, alopecia, platelet count decreased, constipation, decreased appetite, anemia, hypokalemia, diarrhea, and cough.

Most common side effects in patients with gastric cancer were nausea, decreased appetite, anemia, fatigue, blood alkaline phosphatase increased, alanine aminotransferase 

increased, hypokalemia, diarrhea, vomiting, constipation, pyrexia, blood bilirubin increased, and alopecia. 

How much does Enhertu® cost in India?

The enhertu cost in India is reasonable. To procure this breast and stomach cancer medication authentically, you can call or WhatsApp +91-9310090915 or send mail to info@indianpharmanetwork.in.

What are the storage conditions of Enhertu®?

Store vials of Enhertu in a refrigerator at 2-8°C (36-46°F) in the original carton in order to protect from light until time of reconstitution. Avoid freezing. Avoid shaking the reconstituted or diluted solution. 

What are the Highlights of prescribing information for Enhertu®?

Click Here to download full Enhertu prescribing information.

Source - https://bit.ly/3orFBpk

Enhertu an Anti – Cancer Drug

What is Enhertu ?

Enhertu (Fam-trastuzumab deruxtecan-nxki) is used in chemotherapy as a chemo drug and also for Anti – Cancer targeted therapy as an anti cancer drug . 

Enhertu side effects: The most commonly reported side effects of Enhertu are:

• cough
• nausea
• vomiting
• fatigue
• hair loss
• constipation
• anemia
• diarrhea
• decreased appetite
• low white blood cell counts

This medicine also can cause some serious side effects. While these serious effects are less common, it’s crucial to know about them:

Heart problems: Enhertu may be responsible for causing serious heart complications, including a few that don’t have signs/symptoms, such as reduced heart function, and a few that do have signs/symptoms, such as congestive heart failure. Signs/symptoms to monitor for include shortness of breath, swelling of the ankles or legs, cough, or weight gain of more than five pounds in less than 24 hours.

Interstitial lung disease: Interstitial lung disease (ILD) is a general term for such disorders that are responsible for causing inflammation and scarring in the lungs. The scarring makes lung tissue stiff, which makes it tough to breathe. Patients should be precisely monitored for signs of ILD while on treatment with Enhertu and inform your health specialist right away in case you have a dry cough or experience shortness of breath. 

How Enhertu helps in fighting Cancer?

Trastuzumab the antibody part targets and gets attached to the Her2 receptor of the cancer cells . Once the Trastuzumab is attached the chemotherapy part 

(deruxtecan) gets released in the cancer cells and destroys the cancer cells and other surrounding cancer cells . 

What are the ingredients in Enhertu? 

fam-trastuzumab deruxtecan-nxki is the active ingredient in Enhertu and inactive ingredient includes L-histidine, L-histidine hydrochloride monohydrate, polysorbate 80, and sucrose. 

Can you Explain the Trastuzumab and Deruxtecan section of Enhertu in a better way ? 

Yes , Enhertu has been made in combination of 2 different cancer drugs that are Trastuzumab section which is a targeted therapy and designed for find and target the Her2 receptor on cancer cells and Deruxtecan section which destroys the cancer cells after it has been targeted . So it is made by two drugs by joining two different ADC ( Antibody -drug conjugate ) . 

Is enhertu for breast cancer

FDA Approves First Targeted Therapy for HER2-Low Breast Cancer. Today, the U.S. Food and Drug Administration approved Enhertu (fam-trastuzumab-deruxtecan-nxki), an IV infusion for the treatment of patients with unresectable (unable to be removed) or metastatic (spread to other parts of the body) HER2-low breast cancer.

What is dosage form and strength of Enhertu ? Please also tell how it can be taken . 

Enhertu is supplied as an injection of 100 mg lyophilized powder in a single-dose vial , normally given as an IV (intravenous) infusion once enery 3 weeks , still we would suggest to ask a authorised doctor before taking a specific dose of Enhertu , and please don’t take this medicine without the advice of an authenticated doctor .  

What to expect when taking Enhertu? 

Enhertu (Fam-trastuzumab deruxtecan-nxki) is given intravenously, which means this medication is typically delivered directly into the bloodstream through an IV or port. Medicine is prescribed every 3 weeks unless the disease grows or unacceptable adverse reactions develop.

Those who are pregnant or want to get pregnant should not use Enhertu. This medicinal product can be responsible for causing embryo death and birth defects. It’s necessary that women don’t get pregnant while on treatment with Enhertu; effective birth control should be considered. 

Is there hair loss with the patients of Enhertu ?

Yes , hair loss is a common side effect faced by the patients of Enhertu 

own country ? 

Yes Indian pharma network  Named Patient program help’s patient to procure the medicines which are not available or approved in one’s own country . Indian pharma network  provides access to Enhertu (Fam-trastuzumab deruxtecan-nxki) Manufactured by: Daiichi Sankyo, Inc., and Marketed by AstraZeneca Pharmaceuticals LP, Wilmington . 

More - Enhertu: Know about Medication

Important Information About Adcetris Injection

 Adcetris is a specific medication used alone or in combination with other medications to treat adults with certain types of cutaneous or systemic anaplastic large cell lymphoma, peripheral T-cell lymphoma, Hodgkin lymphoma, or mycosis fungoides. Adcetris injection is also used in the treatment of certain other kinds of cancer. Adcetris contains a monoclonal antibody that binds to a CD30 protein, which is found on certain lymphoma cells. This drug helps in destroying cancer cells. Adcetris is a kind of antibody-drug conjugate (ADC). Adcetris contains the drug  Brentuximab Vedotin and SGN-35.

The following table provides a brief yet important deets about Adcetris, so take note of the same:

Manufacturer- Seattle Genetics

Composition - Brentuximab Vedotin: 50 Mg/Vial

Innovator Brand - Brentuximab Vedotin, Adcetris 

Type of Drug - Antibody-Drug Conjugate (ADC)

How it works- Works by reducing the number of cancerous cells in the body

Packaging Type- Bottled

Adcetris 50 mg is the brand/trade name for a generic drug, Brentuximab vedotin, which is an active substance made of a monoclonal antibody designed to kill the cancer cells in the human body. It is used as the targeted therapy for treating lymphoma that has a probability of relapsing or has already relapsed after a stem cell transplant or with some previous anti-cancer medicines. Manufactured by Seattle Genetics, Adcetris is an FDA-approved medicine. If you want to source this medicinal product, knowing the Adcetris injection price in India becomes a bit significant, as there are very few authentic and legitimate suppliers for the same.

 

In this segment, we brief you about the best place you can purchase this medication while divulging deets about the uses of this medicinal product.

Benefits of Adcetris 50 MG

• Treatment of classical Hodgkin lymphoma (cHL):
• It treats newly diagnosed Stage 3 or 4 classical Hodgkin lymphoma in combination with chemotherapy medicines (Adriamycin, vinblastine, and dacarbazine).
• It treats classical Hodgkin lymphoma (cHL) at high risk of coming back or becoming worse after a stem cell transplant.
• It treats classical Hodgkin lymphoma (cHL) after a stem cell transplant fails or after at least 2 combination chemotherapy treatments fail and stem cell transplant is not an option. 

Treatment of T-cell Lymphoma (sALCL): 

• It treats newly diagnosed systemic anaplastic large cell lymphoma or other CD30-expressing peripheral T-cell lymphomas, including angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphomas not otherwise specified, in combination with chemotherapy (cyclophosphamide, doxorubicin, and prednisone).
• It treats systemic anaplastic large cell lymphoma (sALCL) after at least one course of combination chemotherapy treatment fails.
• It treats primary cutaneous anaplastic large cell lymphoma or CD30-expressing mycosis fungoides who have received prior systemic therapy (treatment that reaches and affects the entire body). 

Most common side-effects of Adcetris

The common side-effects of Adcetris are neutropenia, peripheral sensory neuropathy, fatigue, nausea, anemia, upper respiratory tract infection, diarrhea, pyrexia, rash, thrombocytopenia, cough, and vomiting.

Where to buy Adcetris in India

It is an orphan drug, making it extremely rare to find, with limited authentic suppliers of Adcetris and wholesalers of adcetris in the market. Adcetris does not have zillions of suppliers in India, and with just a few in the market, it is absolutely crucial that one makes an informed decision. Hence, IPN (Indian Pharma Network) comes to the rescue by offering an online platform to purchase the hard-to-access medicines at best promising price range. All you need to do is just open the website of IPN (Indian Pharma Network), search for the medication, and request the Adcetris price in India. The team will get back within a reasonable time-span along with the best quotation. IPN (Indian Pharma Network) aims to improve healthcare by delivering most essential medical supplies to ensure timely patient care. 

In addition, you can also reach out to us via +91-9310090915 | TOLL-FREE Number: 1800-889-1064 or you can write at info@indianpharmanetwork.in in order to buy adcetris online in India. 

 

We're one of the most authentic Supplier, Wholesaler, Distributor of Adcetris, based in Noida, India. We're certified by higher authorities like WHO-GDP, GMP and ISO. 

 

Key Takeaways

Adcetris is supplied in a glass vial which must be stored in the refrigerator between 2 degrees to 8 degrees Celsius. It comes only for intravenous (IV) infusion by a health specialist. If you are planning to buy, kindly make sure you check for the Adcetris or Brentuximab vedotin price in India with us.

Possible serious side effects of ADCETRIS: 

• Nerve damage (peripheral neuropathy): Let your health specialist know in case you have any numbness or tingling in your feets or hands or any muscle weakness.

• Allergic and infusion reactions: Let your health specialist know in case you experience symptoms of rash, fever, chills, or breathing problems within 24 hours of infusion. In case you have a reaction, you may be given drugs before treatment with Adcetris.

• Blood complications: Severe cases, including death, of fever with a reduced number of WBCs have occurred with treatment. Severe cases of a reduced number of WBCs, a reduced number of platelets, or a reduced number of RBCs can occur.

• A health specialist will perform blood tests to check the level of blood cells  during Adcetris therapy. You may be given a medicine known as G-CSF. Let your doctor know in case you have a fever of 100.5°F or higher, chills, cough, or pain when you urinate.

• Infections caused by fungi, bacteria, or viruses have occurred.

• Tumor lysis syndrome: TLS is caused by the quick breakdown of cancerous cells. A health specialist will monitor patients for signs/symptoms.

• Patients with severe kidney or moderate/severe liver disease may experience more adverse reactions and deaths than those without kidney or liver complications/problems.

• Liver complications. Severe liver complications, including death, can occur. Let your doctor know in case you feel tired, feel a full stomach, have upper stomach pain, dark urine, or yellow skin and eyes (jaundice).

• Lung complications: Severe lung complications, including death, can occur. Let your doctor know in case you have a new cough, a cough that gets worse, or shortness of breath.

• Skin complications called Stevens-Johnson syndrome and toxic epidermal necrolysis may appear. Let your doctor know in case you have hives, rash, sores in your mouth, or blistering or peeling skin.

Retevmo (Selpercatinib) Capsules Uses

The medicine Retevmo contains Selpercatinib, a kinase inhibitor used in the treatment of patients who have metastatic RET fusion-positive non-small cell lung cancer (NSCLC) and thyroid cancer (namely RET-Mutant Medullary Thyroid Cancer and RET Fusion-Positive Thyroid Cancer). Retevmo capsules are supplied in 40 mg and 80 mg for oral administration. 

Non-Small Cell Lung Cancer

The two major kinds of lung cancer namely; small-cell lung cancer and non-small cell lung cancer (NSCLC). NSCLC (Non-small cell lung cancer) begins when healthy cells in the lung change and grow out of control, forming a mass called a tumor, a lesion, or a nodule. The tumor can begin anywhere in the lung and can be cancerous or benign. When a cancer-causing lung tumor grows, it may shed cancerous cells. Such cells can be carried away in blood or float away in the lymph fluid surrounding lung tissue. Lymph flows through tubes called lymphatic vessels that drain into collecting stations called lymph nodes.

The are 3 types of Non-small cell lung cancer:

• Adenocarcinoma
• Squamous cell carcinoma
• Large cell carcinoma

Healthcare professionals recommend using Retevmo 40 mg and 80 mg in treating patients with metastatic RET fusion-positive non-small cell lung cancer. 

Thyroid Cancer

Thyroid cancer develops in the thyroid. It is a butterfly-shaped gland at the base of the neck. The thyroid gland produces hormones that regulate your metabolism. Hormones released by the thyroid also help control your body temperature, blood pressure and heart rate. 

Thyroid cancer is classified into types based on the kinds of cells found in the tumor. The type is determined when a tissue sample from your cancer is examined under a microscope. The type of thyroid cancer is considered in determining your treatment and prognosis.

The types of thyroid cancer are:

• Papillary
• Follicular
• Medullary
• Anaplastic

Healthcare professionals use Retevmo 80 mg and 40 mg to treat patients with advanced or metastatic RET-mutant medullary thyroid cancer (MTC) who require systemic therapy and advanced or metastatic RET fusion-positive thyroid cancer require systemic therapy and who are radioactive iodine-refractory. 

Cost of Retevmo

Retevmo price in India is economical, and one can purchase this medicine from certified generic medicine suppliers. To know more about this medicine, one can write to us at info@indianpharmanetwork.in and call 18008891064.

Treatment of hereditary Tyrosinemia Type 1 (HT-1 )

 What is HT1 ?

Tyrosinemia type ( HT-1 ) is caused when the body is unable to break down tyrosine

which is one of the protein’s core building block. When the tyrosine is unable to

break down; toxic substances are formed within blood known as succinylacetone.

This clearly shows that if Tyrosinemia isn’t treated, it can cause liver and kidney

damage and other neurological issues.

How many people are affected by Tyrosinemia & is it inherited from both the parents?

Tyrosinemia affects 1 in 100,000 people and must be inherited from both the parents.

Does a specific gender is more prone to have HT-1 ?

Both Male and Female are equally prone to having HT- 1 .

Are people affected by Tyrosinemia never eat proteins ?

No that’s not true though low – protein diet is required in such cases to cause build

up of too much protein in child’s body but they still small amount of protein and

amino acids are required in the body .

Does HT-1 can be cured permanently ?

No not necessarily , those who have HT-1 will likely to manage for entire life .

What is Nitisone ?

It is first drug which has been approved for the treatment of HT-1

Does the dose of Orfadin (Nitisinone )remains same throughout the life ?

The dose of Orfadin depends on the body weight changes of a body , this is a

reason blood tests become necessary to quantify the levels the tyrosine in the blood

.Are there any other versions of Nitisinone available other than Orfadin ?

Yes , Nobel’s Pharma also manufacturer Nitisinone known as Tisinon which is

available in strength’s of 5mg and 10 mg which comes in a pack of 60 capsules .

In what Dosage forms and strengths does Orfadin comes ?

Orfadin comes in capsule form of 2mg , 5 mg , 10 mg and 20 mg . Apart from that it

also comes in oral suspension 4mg/ml .

Can Nitisinone be procured by the patients if not available or approved in

one’s own country ?

Yes , Indian pharma network  Named Patient program help’s patient to procure the

medicines which are not available or approved in one’s own country. Indian pharma network  provides access to both Orfadin (nitisinone) which is marketed by the

company Swedish Orphan Biovitrum International AB, Sweden and Tisinon

(nitisinone)by Nobel Pharma which is a Turkish brand and manufactures drugs for

unmet medical needs.

Read More- Hereditary tyrosinemia type 1 (HT-1) medicine

Venetoclax: Briefed information about the medication

 On May 15'th, 2019, the Food and Drug Administration approved Venetoclax for chronic lymphocytic leukemia. It is used with another drug named obinutuzumab (when CLL has not been previously treated). Or venetoclax is used with another drug named rituximab (when CLL has come back or has not responded to treatment). Venetoclax is also used by itself when CLL has a chromosome deletion and has come back or has not responded to treatment; or has no chromosome deletion and other therapies are not available. 

Chronic Lymphocytic Leukemia is a type of cancer that typically affects the lymph nodes and WBCs known as “B lymphocytes”. In this disease, unhealthy B lymphocytes amplify rapidly and live a bit longer. This causes an increase in the number of unhealthy B lymphocytes in the blood.

Venetoclax works to inhibit a protein in the body known as BCL-2, which helps malignant cells

 survive. Inhibiting BCL-2 helps to destroy and reduce the number of malignant cells.

Ingredients in Venclexta

The medicine Venclexta contains active ingredient as Venetoclax, and as a non-medicinal ingredients it contains: colloidal silicon dioxide, calcium phosphate dibasic, copovidone, polyethylene glycol, polysorbate 80, iron oxide yellow, polyvinyl alcohol, sodium stearyl fumarate, talc and titanium oxide. Venetoclax 50 mg tablets also contain iron oxide black and iron oxide red.

Dosage Forms & Strengths

The medication Venetoclax typically comes in the form of Tablets as following dosage strengths:

• venetoclax 10 mg tablets
• venetoclax 50 mg tablets
• venetoclax 100 mg tablets

Dosing Regimen

The proposed dosing regimen of Venetoclax is always taken exactly as your health specialist tells you. Drink plenty of water while on treatment with Venetoclax to help reduce the risk of getting TLS. Take the tablets through a meal and water persistently everyday. Swallow the pills whole. Healthcare professionals recommend chewing/crushing/breaking the pills. Your doses of Venetoclax may be reduced in some cases, including in case you have severe liver complications, or you are on with certain drugs that may interact with Venetoclax. Your therapy may be interrupted or dose lowered in case you have certain side effects.

Usual dose: Your health specialist will start Venetoclax at a low dose for 7-days. Your health specialist will gradually increase the dose of Venetoclax over the next 4 weeks to the full standard dose. The usual dosage is as follows: 

The starting dose is 20 mg (2 × 10 mg tablets) once daily for 7 days. The dose will be enhanced to 50 mg (1 × 50 mg tablet) once daily for 1-week. The dose will be enhanced to 100 mg (1 × 100 mg tablet) once daily for 1-week. The dosage will be enhanced to 200 mg (2 × 100 mg tablets) once daily for 1-week. The dose will be enhanced to 400 mg (4 × 100 mg tablets) once a day.

If you are taking venetoclax dosage alone, you will stay on the 400 mg per day dose, which is the standard dosage, for as long as required. 

Venetoclax in combination with Obinutuzumab: You will start Venetoclax dosing after receiving your first cycle of obinutuzumab doses. You will receive Venetoclax for 12 months.

Venetoclax in combination with rituximab: You will start your rituximab following the initial 5 weeks of Venetoclax. You will receive the medication Venetoclax for 2 years.

Possible Side Effects from Venclexta    

These are not the entire possible side effects you may feel while on venetoclax. In case you have any venetoclax side effects not listed here, contact your health specialist immediately.

• diarrhea
• constipation
• nausea
• vomiting
• decreased appetite
• weight loss
• stomach pain
• swelling of arms, hands, legs, and feet
• weakness
• mouth sores
• shortness of breath
• rash
• fever
• headache
• dizziness
• feeling tired
• cough
• muscle, bone, back, neck and joint pain
• itching

Venetoclax may be responsible for causing abnormal exam and blood test results. Your health specialist will do certain tests prior to and during the treatment. A health specialist will interpret the results. They will let you know in case there are any abnormalities in tests that might require treatment.

Storage and Handling 

• One should store the vials of Venetoclax at 2–8°C (36–46°F) in the original carton to protect from light. 
• Venetoclax is an antineoplastic product so one should handle this medicine with precautions. 

Price and Availability in India

The Venetoclax price is absolutely reasonable. The prices of this medication usually depend on the pharmaceutical firm or company or wholesaler you visit. Venetoclax is available as a brand name medicine only, a generic version is not yet available.