All about Atriance Injection

 Atriance: Indication 

Atriance is a cancer drug that is sold under the brand name Nelarabine under a valid and recognized prescription. Patients with T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-LBL) whose illness has not responded to or relapsed after treatment with at least two chemotherapy regimens are advised to use Nelarabine. The evidence to support these indications is based on scant data due to the tiny patient populations in these disease situations. 

Nelarabine injection in India is available and can be purchased among reliable suppliers like Indian Pharma Network at reasonable prices. To know more about the drug, you can call us at +91 93100 90915.

Atriance: Dosage and Administration 

It comes in vials as Nelarabine 250 mg. Regular monitoring of complete blood counts, including platelets, is required and only a doctor with training in the use of cytotoxic agents may supervise the administration of Nelarabine. 

• Adults and teenagers (who have reached the age of 16):- 
• For adults and adolescents 16 years of age and older, a dose of 1,500 mg/m2 of Nelarabine given intravenously for two hours on days 1, 3, and 5 and repeated every 21 days is advised. 
• Adolescents and children (under 21 years old) 

Nelarabine should be delivered intravenously by dripping the vein over an hour daily for five days in a row, repeated every three and a half weeks, to children and adolescents (age 21 and under). 

Atriance: Adverse Drug Reactions 

Based on data from 103 adults and 84 pediatric patients, the safety profile from pivotal clinical studies at the indicated doses of Atriance Nelarabine in adults (1,500 mg/m2) and children (650 mg/m2) is based. Fatigue, gastrointestinal, hematological, respiratory, and nervous system issues (somnolence, peripheral neurological disorders, dizziness, hypoaesthesia, paraesthesia, headache), and pyrexia were the side events that occurred the most frequently. The dose-limiting side effect of nelarabine treatment is neurotoxicity. An overdose of Nelarabine has no known cure. Supportive care should be offered following an acceptable clinical practice. So, it is necessary to take doses as prescribed by the doctors, and the emergence of any side effects must be reported as soon as possible. 

Atriance: Composition 

A clear, colorless solution is the Atriance solution for infusion. It comes in transparent glass vials with rubber stoppers covered by aluminum caps. Nelarabine is an active chemical. 5 mg of Nelarabine is contained in each milliliter of Atriance solution for infusion. There are 250 mg of Nelarabine in each vial. The additional ingredients include sodium hydroxide, water for injection, hydrochloric acid, and sodium chloride ( "Atriance contains sodium").

This antineoplastic drug is available in the market and can be purchased at budgeted rates as the Nelarabine injection price is economical. Visit us at https://www.indianpharmanetwork.in/ to know more about the drug. 

Atriance: Mechanism of Action 

A pro-drug of the deoxyguanosine analogue ara-G is Nelarabine. Adenosine deaminase (ADA) quickly demethylates Nelarabine to ara-G, which is subsequently intracellularly phosphorylated by deoxyguanosine and deoxycytidine kinase to yield Nelarabine's 5'-monophosphate metabolite. The active 5'-triphosphate form, ara-GTP, is subsequently created from the monophosphate metabolite. As ara-GTP builds up in leukemic blasts, it is preferentially incorporated into deoxyribonucleic acid (DNA), inhibiting DNA synthesis. Cells die as a result of this. Nelarabine injection cytotoxic effects could be mediated by several pathways. T-cells are more vulnerable to the cytotoxic effects of Nelarabine in vitro than B-cells. 

Atriance: Warnings And Precautions 

Although Atriance price is economical, there are some warnings and precautions associated with Atriance injection- 

• Nelarabine use has been associated with severe neurological responses. These reactions have included peripheral neuropathy, hypoesthesia, which can range from numbness and paresthesias to motor weakness and paralysis, altered mental states like severe somnolence, confusion, and coma, and effects on the central nervous system like convulsions, ataxia, and status epilepticus. 
• Ascending peripheral neuropathies resembling Guillain-Barré Syndrome and reactions linked to demyelination have also been reported. (Refer to section 4.8). 
• Nelarabine's dose-limiting hazard is neurotoxicity. Nelarabine withdrawal has not always resulted in complete recovery from these responses. Nelarabine must be stopped at the first indication of neurological reactions of NCI CTCAE Grade 2 or above, making close monitoring for neurological reactions highly advised. 

Atriance: Drug Interactions 

The key hepatic CYP isoenzymes CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, or CYP3A4 were not appreciably inhibited by Nelarabine or ara-G in vitro. It is not advised to provide nelarabine and adenosine deaminase inhibitors like pentostatin concurrently. Nelarabine's effectiveness may be decreased by concurrent administration, and either active substance's adverse event profile may be altered. 

When the drug is used by following the details provided by the health practitioner, it can be proven useful. For more detail about Nelarabine price, you can visit us at 

Indian Pharma Network does not provide narcotics or sedatives, only medications requiring a licensed physician's prescription.