Tibsovo: Indication and Usage

 Tibsovo: Indication and Usage

Tibsovo is an FDA-approved isocitrate dehydrogenase-1 (IDH1) inhibitor used to treat adult patients who have a susceptible IDH1 mutation as detected by an FDA-approved test with:

AML (Acute Myeloid Leukaemia) is a kind of blood cancer.

AML patients over the age of 75 who have comorbidities that prevent vigorous induction chemotherapy from being administered AML that has relapsed or is refractory

Cholangiocarcinoma, either localized or metastatic

 Patients suffering from locally advanced or metastatic cholangiocarcinoma who have previously been treated

This effective medication is available on the market and can be obtained from any reputable dealer. Furthermore, the Tibsovo price in India is tiny and incredibly reasonable, making it simple to incorporate into therapy. 

Tibsovo: Dosage and Administration

Tibsovo 250 mg Tablets are available. Tibsovo should be taken once a day orally until disease progression or severe toxicity occurs.

Tibsovo can be administered with or without food. Tibsovo should not be used with a high-fat meal due to an increase in Tibsovo concentration [see Warnings and Precautions (5.2) and Clinical Pharmacology]. Tibsovo pills should not be crushed or divided. Tibsovo pills should be taken orally at the same time every day. If a Tibsovo dose is vomited, do not replace it; rather, wait until the next scheduled dose is due. If a Tibsovo dose is missed or not taken on time, it should be given as soon as possible and minimum 12 hours before the next scheduled dose. Return to your regular schedule the next day. Do not take two doses within 12 hours of each other. 

Tibsovo: Warnings and Precautions 

Electrocardiograms and electrolytes should be checked for QTc interval prolongation. If QTc interval prolongation occurs, reduce or pause the dose, then resume the dose or discontinue Tibsovo permanently.

Guillain-Barre Syndrome (GBS): Keep a look out for indications and symptoms of new motor and/or sensory impairments in patients. Quit Tibsovo for good if you have Guillain-Barré syndrome.

This powerful pharmaceutical is on the market and may be obtained from any respectable vendor. Furthermore, the Tibsovo price in India is economical, making it simple to incorporate it into treatment. 

Tibsovo: Drug Interaction

Strong or moderate CYP3A4 inhibitors: Reduce TIBSOVO dosage when using strong CYP3A4 inhibitors. Patients should be closely watched for signs of QTc interval prolongation.

 Inducers of CYP3A4: Avoid using TIBSOVO (7.1, 12.3) simultaneously.

If you have sensitive CYP3A4 substrates, avoid using TIBSOVO (7.2, 12.3) at the same time.

Avoid taking QTc prolonging medications with TIBSOVO. Healthcare professionals should monitor the patients for an increased risk of QTc interval prolongation if coadministration is unavoidable.

If someone develop signs and symptoms of differentiation syndrome, the healthcare provider may treat the patient with a corticosteroid medicine or a medicine called hydroxyurea and may monitor you in the hospital.

You can easily buy Tibsovo tablets from India at a lower cost through Indian Pharma Network at a more reasonable and pocket-friendly price. We are the most dependable and trustworthy generic pharmaceutical suppliers in India. You can visit us at 

Tibsovo: Adverse Reactions

Although the price of Tibsovo is reasonable, the following drug interactions must be understood before using the drug. Inquire with your doctor for further information.

The most common adverse symptoms (20%) in AML patients were fatigue, arthralgia, leukocytosis, diarrhea, edema, nausea, dyspnea, mucositis, and ECG. QT prolongation symptoms include rash, cough, decreased appetite, myalgia, constipation, and pyrexia.

The most common laboratory abnormalities (20%) in AML patients were hemoglobin decrease, calcium decrease, sodium decrease, magnesium decrease, uric acid decrease, potassium decrease, alkaline phosphatase decrease, aspartate aminotransferase decrease, phosphate decrease, and creatinine decrease. 

The most common side effects (15%) in patients with cholangiocarcinoma were fatigue, nausea, stomach discomfort, diarrhea, cough, decreased appetite, ascites, vomiting, anemia, and rash.

The most common laboratory abnormalities in cholangiocarcinoma patients (10%) were reduced hemoglobin, increased aspartate aminotransferase, and high bilirubin.

Tibsovo: Mechanism of Action

Ivosidenib is a small molecule inhibitor that prevents the mutant isocitrate dehydrogenase 1 (IDH1) enzyme from working. Susceptible IDH1 mutations in AML patients are those that result in increased 2-hydroxyglutarate (2-HG) levels in leukemia cells and where efficacy is predicted by 1) clinically meaningful remissions with the recommended dose of ivosidenib and/or 2) inhibition of mutant IDH1 enzymatic activity at ivosidenib concentrations sustainable at the recommended dosage using validated methods. The R132H and R132C alterations are the most common in AML patients. 

Ivosidenib inhibited selected IDH1 R132 mutants in vitro at significantly lower dosages than wild-type IDH1. In mouse xenograft models of AML with an IDH1 mutation, ivosidenib inhibited the mutant IDH1 enzyme, lowering 2HG levels and increasing myeloid growth in vitro and in vivo. In blood samples from patients with AML with mutant IDH1, ivosidenib reduced ex-vivo 2-HG levels, blast counts, and the fraction of mature myeloid cells. 

Tibsovo: Description about the drug

The chemical formula is C28H22ClF3N6O3, and the molecular weight is 583.0 g/mol. In aqueous solutions with pH values ranging from 1.2 to 7.4, ivosidenib is largely insoluble.

Tibsovo (ivosidenib) film-coated 250 mg tablets are available for oral use. Colloidal silicon dioxide, croscarmellose sodium, hypromellose acetate succinate, magnesium stearate, microcrystalline cellulose, and sodium lauryl sulfate are among the inactive ingredients in each tablet. The tablet coating contains FD&C blue #2, hypromellose, lactose monohydrate, titanium dioxide, and triacetin. 

The drug can be obtained from any generic and innovative provider who has a license to do so under a valid and recognized prescription and who follows the relevant regulations. Indian Pharma Network is one of the most trusted and dependable generic pharmaceutical suppliers, and you can buy Tibsovo online from us at extremely low prices.