Enhertu: Dosage and Mechanism of action

INDICATION AND USAGE

For adults with HER2-positive breast cancer, which has spread to other parts of the body or cannot be removed by surgery, ENHERTU is used as prescribed by the doctor. It has proven itself an efficient drug for cancer that is sold at fairly good prices with uncompromised effects. It is available in the market, and anyone with a valid prescription can buy ENHERTU online in India. This effective drug is also given to adults suffering from HER2-positive advanced gastric cancer or gastroesophageal junction adenocarcinoma, which can be metastatic or has spread to other parts of the body. Enhertu is used in patients on its own who have taken one or more HER2-targeted treatments.

DOSAGE AND ADMINISTRATION

ENHERTU is a prescriptive drug that can only be obtained and used under the prescription and supervision of an expert cancer specialist doctor. The drug is available as enhertu 100 mg injection, which comes in lyophilized powder in a single-dose vial for reconstitution.enhertu is given intravenously only without any push or bolus. The recommended dose for HER2-positive breast cancer is 5.4 mg/kg once every 3 weeks of a 21-day cycle. 

For HER2-positive advanced gastric cancer, the recommended dosage of ENHERTU for gastric cancer is 6.4 mg/kg given by dripping the vein once every 3 weeks of a 21-day cycle.

MECHANISM OF ACTION

The active substance in Enhertu is trastuzumab deruxtecan. It is made up of two active components that are linked together. It is a HER2-directed antibody-drug conjugate. The antibody is a humanized anti-HER2 IgG1. DXd is a topoisomerase I inhibitor that is small in size and gets attached to the antibody by a cleavable linker. Its binding is followed by HER2 on tumor cells, by lysosomal enzymes, fam-trastuzumab deruxtecan undergoes internalization and intracellular linker cleavage. The membrane-permeable DXd causes DNA damage and apoptotic cell death upon its release.

The FDA approved fam-trastuzumab deruxtecan on August 5, 2022, for use in adult patients with unresectable or metastatic HER2-low breast cancer, and it is available in India. For more details about its mechanism of action and to check for ENHERTU price, you can visit us at Indian Pharma Network, +91 93100 90915.