Tukysa The Breakthrough Cancer Drug

INDICATION AND USAGE

Tukysa is a cancer medicine that is a kinase inhibitor. This potent drug is used to treat HER2-positive breast cancer, which is locally advanced or has spread to other parts of the body. This means the cancerous cells produce a protein on their surface, HER2, which stimulates the growth of cancer.

The medicine Tukysa is used with two other medicines, capecitabine, and trastuzumab. It is used after at least two other treatments for HER2-positive cancer have already been given and tried. This efficient drug is within reach in the market, and that too at affordable rates as Tukysa price is economical. 

For more information about the drug, you can call us at +91 9310090915 and ask for further detail regarding Tukysa.

DOSAGE STRENGTH

It is available as yellow, film-coated, oval Tukysa 150 mg tablets and round 50 mg tablets containing tucatinib, its active pharmaceutical ingredient. This drug can only be obtained with a prescription, and treatment should be started and supervised by an expert experienced in giving cancer treatments. 

Tukysa can cause severe hepatotoxicity, and based on the severity of hepatotoxicity, the dose might be interrupted or reduced, and in some cases, it is permanently discontinued. So, the dose must be selected by the doctor only in order to have better and enhanced effects with the least toxicity. 

DOSAGE AND ADMINISTRATION

Tukysa is given orally, that is, by mouth, and the recommended dose is 300 mg twice a day. Patients are also treated with capecitabine and trastuzumab on specific days of a 21-day cycle.

Treatment can continue as long as the cancer does not get worse, there is any progression, and side effects are bearable. The doctor recommends a reduced dose of Tukysa if certain side effects occur, or the treatment may be temporarily or permanently stopped.

 For patients with severe hepatic impairment, taking a dosage of 200 mg orally twice daily is recommended. To know more about Tukysa tablet cost in India, you can visit us at www.indianpharmanetwork.in.

MECHANISM OF ACTION

The active substance in Tukysa is tucatinib. It is a type of cancer medicine called a tyrosine kinase inhibitor. Tucatinib inhibits the phosphorylation of HER2 and HER3, which results in the inhibition of downstream MAPK and AKT signaling and cell proliferation. It showed antitumor activity in HER2-expressing tumor cells by attaching to the HER2 protein on the cancer cells, so its action is blocked. As HER2 helps cancer cells to grow and divide, thus blocking it helps to stop these cells from growing. This causes them to die, controlling the growth of cancer. 

The desired effect can be obtained by taking a certain dose of the drug as recommended by the doctor. To buy Tukysa tablets online at affordable rates, you can visit us or call us at +91 9310090915.

ADVERSE DRUG REACTION

Like any other cancer drug, some Tukysa side effects are accompanied by the ill effects of the drug. The most common side effects associated with Tukysa are nose bleeds, diarrhea, nausea, vomiting, stomatitis which is inflammation of the mouth, rash, arthralgia, palmar-plantar erythrodysesthesia, anemia, increases in the blood levels of liver enzymes ALT and AST and bilirubin, and weight loss. This may affect more than 1 in 10 people using Tukysa.

Other more serious side effects caused due to Tukysa, which are in more than 1 in 20 people using the drug, are diarrhea and increased ALT and AST, hepatotoxicity, nausea, and vomiting may also be serious and can be fatal.

STORAGE

TUKYSA 50 mg and 150 mg tablets are supplied as yellow, film-coated, round, and oval tablets, respectively. Each tablet is debossed with “TUC” on one side and “50” on the other side for 50 mg and “150” in case 150 mg is packaged.

It is stored at a controlled room temperature from 20ºC to 25ºC (68ºF to 77ºF). Dispense to the patient in the original container only. It is stored in the original container to protect it from moisture. The cap should be securely replaced each time after opening. Desiccant needs not be discarded. Once opened, use within 3 months. Discard any unused tablets 3 months after opening the bottle. To seek the price of TUKYSA in India, you can call us at +91 9310090915.

DRUG INTERACTIONS

Although the cost of tucatinib is affordable, it has some following drug interactions that need to be known before using the drug. For more detail, ask your doctor.

Strong CYP3A Inducers or Moderate CYP2C8 Inducers: concomitant use of strong CYP3A inducers or moderate CYP2C8 inducers should be avoided.

Strong CYP2C8 Inhibitors: Avoid concomitant use as it reduces the Tukysa dose if concomitant use cannot be avoided. 

CYP3A Substrates: Avoid co-administering use with CYP3A substrates. As minimal concentration changes may lead to serious or life-threatening toxicities, which can be fatal.

P-gp Substrates: P-gp substrates dose should be reduced, as minimal concentration changes may lead to serious or fatal toxicities.