Trodelvy: A New Era in Cancer Treatment

What is Trodelvy?

TRODELVY is a cancer drug that is used in the treatment of adults suffering from locally advanced or metastatic triple-negative breast (mTNBC) cancer and locally advanced or metastatic urothelial cancer (mUC). It is a trop-2-directed antibody and topoisomerase inhibitor conjugate drug used at prescribed and recommended doses according to body weight. It is given intravenously only, and the Trodelvy injection price is economical, and it can be bought by any recognized supplier. It is given in the vein by drip on day 1 and day 8 of the repeating 3-week cycle. Treatment may be continued for as long as it remains effective. It has the active ingredient, sacituzumab govitecan, which is responsible for the action of TRODELVY by attaching to the antibody by the linker

Dosage and Administration

It comes as 180 mg lyophilized powder in single-dose vials for reconstitution to be given intravenously. It is given on the basis of weight, and the recommended dose is 10 mg/kg, administered as an IV infusion once weekly. It is also available in 200mg vials, and we supply trodelvy 200 mg vials in Indian against a valid prescription.

Before administering Trodelvy, antipyretic medication is given to the patient to induce nausea and vomiting, which are caused due to an infusion reaction. Antipyretic drugs act as H1 and H2 blockers, and those who have prior infusion reactions are given corticosteroids. After premedication, Trodelvy is given for 3 hours intravenously; during and after 30 minutes, any kind of infusion-related reactions are observed. 

Availability In India

Trodelvy has been compared with standard treatment in one of the main studies, which had 529 patients with metastatic or locally advanced triple-negative breast cancer who received two or more prior systemic (whole-body) treatments, including at least one of them for advanced disease. Patients who took Trodelvy lived for an average of 4.8 months without cancer progression and getting it worse than as compared with 1.7 months for the patients who took standard treatment. Patients on Trodelvy lived for an average of 11.8 months compared with 6.9 months for patients on standard treatment.

Trodelvy is available in India through various generic medication suppliers and the TRODEDLVY injection price in India is pocket-friendly, and anyone with a prescription can purchase it easily.

 Mechanism of action

The active pharmaceutical ingredient in Trodelvy is Sacituzumab govitecan-hziy which consists of two active components that are a monoclonal antibody ( which is a kind of protein ) that has been linked to a small molecule, SN-38. The monoclonal antibody has been made to recognize and attach to Trop-2(a kind of protein in many breast cancer cells). When it is attached, and the drug is used up by the cell, then SN-38 becomes active. SN-38 is a cancer medicine that belongs to the group topoisomerase inhibitors. It blocks an enzyme called topoisomerase I, which is involved in copying cell DNA needed to make new cells. By blocking the enzyme, cancer cells are prevented from multiplying and eventually die. Trodelvy's benefits

are greater than its risks; that's why it is approved by FDA, and anyone with a prescription can buy trodelvy in India.

Adverse Drug Reaction

Like any other medication, it comes with some undesired side effects. The most common side effect caused by taking Trodelvy is diarrhea, Nausea (feeling of being sick), low count of neutrophils( they are a kind of WBC which help to fight against infection), loss of hair which is called alopecia, anemia ( low levels of hemoglobin, causes pale skin and tiredness ). These common ADRs affect more than 1 in 5 people who are undergoing treatment. Other common side effects include loss of appetite, constipation, cough, belly pain, and vomiting. Vomiting and Nausea can also occur during the time of infusion, so to prevent these, antipyretics are given as premedication.

The most common serious side effects are febrile neutropenia which is low white blood cell counts with fever due to infection and diarrhea. Well, this medication is all safe to use and is FDA approved.

Moreover, the cost of Trodelvy in India is economical and budget-friendly, and it should be used under the influence of expert medical supervisors of its specialty.

 Measures to ensure safe and effective use

While preparing in an infusion bag, a sterile syringe is used in order to preserve aseptic practice and make the preparation safe from any kind of contamination. Do not shake, but gently swirl. It is light-sensitive, so it needs to be protected from light and must be stored in cool and shady places. After mixing, if there is any precipitation or cloudy substance forming, don't use the preparation and discard it.

As for all medicines, data on the use of Trodelvy are continuously monitored. Predicted side effects reported with Trodelvy are carefully evaluated, and any necessary action is taken to protect patients. One can ask his pharmacist or healthcare provider for information about trodelvy that is written for health professionals.

During intravenous infusion, too, the patient must be carefully observed. Trodelvy injections are available, and the cost of trodelvy injection is budget friendly as compared to other medications of the same line. For more information and details, Contact us: Indian Pharma Network | Toll-Free:- 1800 889 1064.