Kineret For Rheumatoid Arthritis

 Kineret: Availability in India

Patients with moderately to highly active rheumatoid arthritis who have received at least one disease-modifying antirheumatic medication (DMARD) but failed to manage signs and symptoms or delay the course of structural damage are prescribed kineret injection. These patients must be 18 years of age or older. 

It is also used to treat Neonatal-Onset Multisystem Inflammatory Disease (NOMID). 

It is provided by Indian Pharma Network, and you may purchase it there at a fair price. 

 Dosage and Administration 

There is a 100 mg/0.67 mL subcutaneous injectable solution available. Doses between 20 and 100 mg are possible with a graduated syringe. Kineret is injected subcutaneously, or beneath the skin, to deliver the medication. Kineret 100 mg once daily is the recommended dosage for treating rheumatoid arthritis, and it should be taken roughly the same time each day. The dosage for familial Mediterranean fever, Still's illness, and CAPS is based on the patient's weight and the severity of the condition. Patients with CAPS must be at least 8 months old and 10 kg in weight to receive treatment. Take 100 mg of COVID-19 once a day for 10 days.      

KFDA Approved 

Kineret was given the go-ahead to treat RA and Cryopyrin-Associated Periodic Syndromes (CAPS) on November 14, 2001. Human interleukin-1 receptor antagonist (IL-1Ra) is marketed as Kineret (anakinra) and is available in the recombinant, non-glycosylated form. A single methionine residue has been added to the amino terminus of Kineret, which makes it different from native human IL-1Ra. Kineret has a molecular weight of 17.3 kilodaltons and 153 amino acids. It is created using a bacterial expression system from E. coli and recombinant DNA technologies.

Storage

Glass single-use syringes with 27 gauge needles are used to administer Kineret. Each prefilled glass syringe has a 0.67 mL volume and weighs 100 milligrammes of anakinra. Anakinra is included in 100 milligrams of the whole syringe. A 4 x 7 syringe dispensing pack with 28 syringes is available to administer Kineret.

 One should store Kineret between 2 and 8 degrees Celsius or 36 and 46 degrees Fahrenheit. It must be protected from light, not torefrozen, or disturbed.

Mechanism of Action

Kineret (anakinra) is a recombinant, nonglycosylated form of the human interleukin-1 receptor antagonist (IL-1Ra). Immunosuppressive drugs work by reducing immune system function. An artificial replica of a human protein called "human interleukin 1 receptor antagonist," anakinra blocks the body's interleukin 1 receptors. High levels of this interleukin production are present in rheumatoid arthritis patients, which causes joint inflammation and, ultimately, joint damage. Additionally, it fuels the inflammation connected to CAPS, familial Mediterranean fever, and Still's illness. There is no binding site left because anakinra prevents the action of interleukin 1 by attaching to the receptors where interleukin 1 would ordinarily attach. The indications and symptoms of many ailments are eventually relieved.

Kineret injection is offered for a reasonable and cost-effective price, and for more information on Kineret cost, contact us at Indian Pharma Network | +91 93100 90915(Toll-Free).

Adverse Reactions

Rheumatoid Arthritis (RA) The most frequent side effects (incidence 5%) are injection site reactions, rheumatoid arthritis aggravation, upper respiratory tract infections, headaches, nausea, diarrhea, sinusitis, arthralgia, and stomach discomfort.

NOMID- The most frequently reported adverse effects (incidence >10%) during the first six months of treatment were injection site reactions, headaches, vomiting, arthralgia, pyrexia, and nasopharyngitis.

Only with a prescription can one receive Kineret, and only a licensed physician should initiate and oversee treatment. The kineret injection is available fairly and cheaply 

Drug Interaction

There have been no studies on medication interactions involving humans. The clearance or toxicologic profiles of either drug did not significantly change after methotrexate and Kineret administration to rats in toxicologic and toxicokinetic studies. 

TNF Blocking Agents: Studies have shown that patients taking concurrent Kineret and etanercept therapy have a greater incidence of serious infections than patients getting etanercept alone. In 2% of individuals receiving Kineret and etanercept simultaneously, neutropenia (ANC 1 x 109/L) developed. Combining Kineret with TNF-blocking drugs is not recommended.

Kineret can only be obtained with a prescription; only a qualified medical professional should start and manage treatment. The cost of Kineret injection is reasonable and accessible; for additional details, 

Use In Specific Population 

• When a young person has NOMID, Kineret is advised for geriatric use. Due to the higher prevalence of infections in the senior population as a whole, care should be taken when treating the elderly.
• Renal dysfunction: Because this medication is believed to be mostly removed through the kidneys, patients with impaired renal function may be more vulnerable to negative drug responses. 

Kineret should only be used under the supervision of a licensed medical professional, and a prescription is required to obtain it. 

Warnings and Precautions

• Stop using the RA medication if a serious infection develops. Patients with NOMID should weigh the potential risks of quitting Kineret therapy against the possibility of a NOMID flare. Starting Kineret shouldn't be done by patients who have active infections. 
• Combining it with drugs that block tumor necrosis factor (TNF) is not recommended.
• There have been documented cases of angioedema and anaphylactic reactions, among other hypersensitivity events. 
• Kineret treatment has not been demonstrated to affect the development of cancer or active or persistent infections.
• Live vaccines shouldn't be given combined with Kineret.
•  Before beginning Kineret therapy, neutrophil levels should be assessed every three months while on Kineret and then every six months for up to a year afterwards. 
• Kineret injection is priced fairly and rationally; for more information on the medication and Kineret 100 mg/0.67ml,