Unleash Your Inner Glow with Atriance Injection

Atriance: Available in India

Atriance is a cancer medicine available with a legal and authorized prescription under the brand name Nelarabine. Nelarabine is prescribed for patients with T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-LBL) who have not responded to or relapsed following at least two chemotherapy regimens. The evidence to support these indications is limited due to small patient populations in particular illness scenarios.

Nelarabine injection in India is available in the market, and any reliable vendor, such as Indian Pharma Network, can provide it at a fair price. Please contact us at +91 93100 90915 to understand more about the drug.

Dosage and Administration

Nelarabine comes in vials of 250 mg. Complete blood counts, including platelets, must be examined on a regular basis, and Nelarabine administration can only be overseen by a clinician who has been educated in the use of cytotoxic medications.

• Adults and adolescents (those above the age of 16): for adults and adolescents 16 years of age and older, a dose of 1,500 mg/m2 nelarabine administered intravenously over two hours on days 1, 3, and 5 and repeated every 21 days is indicated.
• Nelarabine should be given intravenously to children and teens (age 21 and younger) by dripping the vein for an hour every day for five days, then every three and a half weeks.

Because the Nelarabine injection price is low, this antineoplastic drug is widely available on the market and may be obtained at reasonable costs. 

Side Effects of the drug

The safety profile for Atriance Nelarabine at the approved doses in adults (1,500 mg/m2) and children (650 mg/m2) is based on data from 103 adults and 84 pediatric patients from pivotal clinical studies. Fatigue, gastrointestinal issues, hematological issues, respiratory issues, nervous system concerns (somnolence, peripheral neurological disorders [sensory and motor], dizziness, hypoaesthesia, paraesthesia, headache), and pyrexia were the most common adverse effects. The adverse consequence of nelarabine therapy that is dose-limiting is neurotoxicity. Overdose of nelarabine has no known therapy. Acceptable clinical practice requires the provision of supportive care. As a result, it is vital to follow the dosage instructions and report any side effects as soon as possible.

Atriance: Composition

Atriance infusion solution is a clear, colorless fluid. It comes in transparent glass vials with rubber stoppers and aluminum lids. The active ingredient is nelarabine. Atriance solution for infusion contains 5 mg of nelarabine per milliliter. Atriance 250 mg contains nelarabine in each vial. Sodium hydroxide, injection water, hydrochloric acid, and sodium chloride are among the other constituents ("Atriance contains sodium").

Mechanism of Action

Nelarabine is a prodrug of ara-G, a deoxyguanosine analog. Adenosine deaminase (ADA) rapidly demethylates nelarabine to ara-G, which is subsequently intracellularly phosphorylated by deoxyguanosine kinase and deoxycytidine kinase to yield nelarabine's 5'-monophosphate metabolite. The active 5'-triphosphate form, ara-GTP, is then formed from the monophosphate metabolite. Ara-GTP primarily binds to deoxyribonucleic acid (DNA) in leukemic blasts, reducing DNA synthesis. Cells die as a result of this. The cytotoxic effects of Atriance injection could be mediated by a variety of mechanisms. T-cells are more vulnerable to the cytotoxic effects of nelarabine in vitro than B-cells. 

Warnings And Precautions

•  Nelarabine use has been linked to severe neurological symptoms. Peripheral neuropathy, hypoesthesia (which can range from numbness and paresthesias to motor weakness and paralysis), altered mental states such as severe somnolence, confusion, and coma, and effects on the central nervous system such as convulsions, ataxia, and status epilepticus have all been reported.
• Ascending peripheral neuropathies similar to Guillain-Barré Syndrome have also been documented, as have reactions related to demyelination. (See Section 4.8).
• Neurotoxicity is the dose-limiting danger of nelarabine. Withdrawal from nelarabine has not always resulted in complete recovery from these effects. Nelarabine must be discontinued at the first sign of NCI CTCAE Grade 2 or higher neurological reactions, making frequent monitoring for neurological events highly recommended.

Please visit https://www.indianpharmanetwork.in/  for more information about Nelarabine price. Indian Pharma Network only offers drugs that require a prescription from a licensed physician and does not sell narcotics or sedatives.

 Drug Interactions

Despite the low Atriance price, there are some drug interactions associated with Atriance injection. 

It is not suggested to take nelarabine with adenosine deaminase inhibitors like pentostatin at the same time. Concurrent use of nelarabine may impair its effectiveness and/or affect the adverse event profile of any active medicine.

It can be proved to be beneficial when the drug is used in line with the health practitioner's advice.

Use in Specific Population

• Pregnancy- There is no or little data on the usage of nelarabine in pregnant women.

Animal studies have revealed reproductive harm (see section 5.3). The potential risk to people is unknown; nevertheless, exposure during pregnancy is likely to result in fetal abnormalities and deformities. Nelarabine should be avoided during pregnancy unless absolutely required. If a patient falls pregnant while using nelarabine, they should be warned of the potential risks to the fetus.

• Lactation- The presence of nelarabine or its metabolites in human breast milk is unknown. A risk to the newborn/infant cannot be ruled out. Breastfeeding should be halted when using Atriance.

You can refer us to ask for more information about the drug. We will be happy to help as we are the most trusted supplier. You can also buy Atriance online from Indian Pharma Networks. Visit us at https://www.indianpharmanetwork.in/ for further assistance.

Effect on Fertility

The effect of nelarabine on human fertility is unknown. Unwanted consequences on fertility are possible based on the compound's pharmacological activity. As needed, patients should be counseled about family planning.

During nelarabine treatment, both sexually active men and women should use effective contraceptive techniques. Men who have partners who are pregnant or may get pregnant should use condoms during nelarabine treatment and for at least three months after stopping the medication.

To know more about Atriance injection cost, Indian Pharma Networks offers the most reliable and efficient rates, so you can truly rely on this.

 Precautions for Disposal and other handling

The following measures should be followed for the handling and disposal of cytotoxic anti-tumor medical products: 

• Staff should be instructed on how to handle and transfer the medicinal product.
• Pregnant employees should not be allowed to work with this medication.
• Personnel handling/transferring this therapeutic product should wear protective clothing, including a mask, goggles, and gloves.
• All administrative or housekeeping things, including gloves, should be placed in high-risk waste disposal bags for cremation at high temperatures. Any liquid waste generated during the preparation of the nelarabine solution for infusion should be flushed with a significant volume of water. Accidental skin or eye contact should be treated immediately with substantial amounts of water. Any unused medication or rubbish should be disposed of in accordance with local regulations.

Now, you can buy Atriance injection online in India at very pocket-friendly rates through Indian Pharma Network by visiting us at https://www.indianpharmanetwork.in/. We are a group of highly qualified professionals in the pharmaceutical Industry having more than 20 years of experience in Specialty Pharmaceutical distribution.

Use in Elderly Patients

Although the Atriance injection price is inexpensive, this medication is being monitored more closely. This will enable the rapid detection of new safety information. Any potential adverse reactions should be reported by healthcare experts. Clinical studies of nelarabine did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently from younger patients. In an exploratory analysis, increasing age, especially age 65 years and older, appeared to be associated with increased rates of neurological adverse events.

It comes as Atriance 250mg 50 ml, but sometimes overdosing can happen. Although, there have been no reports of overdoses. In clinical studies, nelarabine was given to a pediatric patient at a dose of 75 mg/kg (approximately 2,250 mg/m2) daily for 5 days to 5 adult patients at a dose of 60 mg/kg (approximately 2,400 mg/m2) daily for 5 days, and to a further 2 adults on days 1, 3 and 5. Overdose of nelarabine is likely to cause severe neurotoxicity (perhaps including paralysis and coma), myelosuppression, and death. Two patients had substantial grade 3 ascending sensory neuropathy at a dose of 2200 mg/m2 given on days 1, 3, and 5 every 21 days. The two patients' MRIs revealed results consistent with a demyelinating process in the cervical spine.

Overdose of nelarabine has no recognized antidote. Supportive care should be delivered in accordance with acceptable clinical practice.

Side Effects

• Infections and infestation- In the adult population, there was one further report of biopsy-confirmed progressive multifocal leukoencephalopathy. There have been cases of opportunistic infections, which can be fatal, in individuals taking nelarabine medication.

• Nervous system disorder- There have been reports of episodes associated with demyelination and ascending peripheral neuropathies that look like Guillain-Barré syndrome.
• Neoplasms benign and malignant (including cysts and polyps)-   Tumor lysis syndrome – 7 cases
• And there are some general Blood and lymphatic system disorders, Metabolism and nutrition disorders, Psychiatric and nervous system disorders, eye, vascular, Respiratory, thoracic and mediastinal disorders, Hepatobiliary disorders, Musculoskeletal and connective tissue disorders, and General disorders, and administration site conditions. Atriance injection cost in India is highly economical and can be purchased under fair prices.

Reproduction toxicity As given at levels approximately 24% of the adult human dose on an mg/m2 basis during organogenesis, nelarabine induced increased occurrences of fetal malformations, abnormalities, and variations in rabbits as compared to controls. Cleft palate was seen in rabbits given around twice the adult human dose, absent policies in rabbits given roughly 79% of the adult human dose, and absent gallbladder, accessory lung lobes, fused or additional sternebrae, and delayed ossification at all doses. Rabbits given a dose roughly double the adult human dose had lower maternal and fetal body weight gain.